The role of α2-agonists in neurosurgery

被引:60
作者
Cormack, JR
Orme, RM
Costello, TG
机构
[1] St Vincents Hosp, Dept Anaesthet, Melbourne, Vic, Australia
[2] Royal Melbourne Hosp, Dept Anaesthet, Melbourne, Vic, Australia
关键词
alpha(2)-agonists; clonidine; dexmedetomidine; neurosurgery; anaesthesia;
D O I
10.1016/j.jocn.2004.06.008
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
alpha(2)-agonists have been extensively used and studied in anaesthesia and intensive care medicine. A list of benefits includes anxiolysis, blood pressure stabilization, analgesia, anaesthetic sparing effects and sedation without respiratory depression or significant cognitive impairment. Fear of inadvertent hypotension, bradycardia or post-operative sedation, and the variability of the haemodynamic response to different doses or rates of administration, have meant that universal acceptance in clinical practice has not yet been seen. Recently, the actions of these agents on the alpha(2)-adrenoreceptor and the imidazoline receptor have been more accurately identified, helping to explain the differences between the actions of various agents. The two readily available agents, clonidine and dexmedetomidine have already been used in many different anaesthetic situations, for a wide variety of surgical procedures. We believe that both of these alpha(2)-agonists are useful adjuncts for the management of the neurosurgical patient during surgery, and in the intensive care unit. (c) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:375 / 378
页数:4
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