Demonstration of in vitro interaction between tumor suppressor lysyl oxidase and histones H1 and H2: definition of the regions involved

被引：58

作者：

Giampuzzi, M ^{[1
]}

Oleggini, R ^{[1
]}

Di Donato, A ^{[1
]}

机构：

[1] Ist Giannina Gaslini, Lab Nefrol, I-16147 Genoa, Italy

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS | 2003年 / 1647卷 / 1-2期

关键词：

lysyl oxidase; elastin; lysine-rich histone;

D O I：

10.1016/S1570-9639(03)00059-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lysyl oxidase (LOX) is the enzyme that cross-links extracellular collagen and tropoelastin and is involved in tumor suppressor activity. Based on the existent homologies between lysine-rich regions of tropoelastin and the "lysine-rich" histone H1, we tested the possibility that HI could be a new nuclear target. Our study shows that LOX could actually interact specifically not only with histone H1, but also with historic H2. Mechanisms and significance of these interactions are discussed in detail. (C) 2003 Elsevier Science B.V All rights reserved.

引用

页码：245 / 251

页数：7

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