Improving the enantioselectivity of Candida rugosa lipase in the kinetic resolution of racemic methyl 2-(2,4-dichlorophenoxy)propionate

被引：21

作者：

Cipiciani, A ^{[1
]}

Cittadini, M ^{[1
]}

Fringuelli, F ^{[1
]}

机构：

[1] Univ Perugia, Dipartimento Chim, I-06100 Perugia, Italy

来源：

TETRAHEDRON | 1998年 / 54卷 / 27期

关键词：

D O I：

10.1016/S0040-4020(98)00422-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Racemic methyl 2-(2,4-dichlorophenoxy)propionate (+/-)-1, was subjected to hydrolysis in water and in a series of two-phase aqueous organic media in the presence of Candida rugosa lipase (CRL). The biocatalytic material used was the commercial preparation and enzyme purified by using different procedures. The (+)-R- and (-)-S-2-(2,4-dichlorophenoxy)propionic acids (3) were obtained in excellent yield and high enantiomeric excess when the hydrolysis of (+/-)-1 was performed in water/benzene in the presence of 2-propanol treated CRL. The kinetic resolution of (+/-)-1 was scaled-up. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7883 / 7890

页数：8

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