A prospective, randomized trial of nifedipine vs. ritodrine in threatened preterm labor

被引:50
作者
García-Velasco, JA [1 ]
González, AG [1 ]
机构
[1] Hosp La Paz, Dept Obstet & Gynecol, Madrid, Spain
关键词
nifedipine; ritodrine; preterm labor; Doppler ultrasound;
D O I
10.1016/S0020-7292(98)00053-8
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objectives: To compare the tocolytic efficacy and maternal tolerance of nifedipine with ritodrine in the management of threatened preterm labor. Methods: Prospective randomized study of 52 singleton pregnancies with preterm labor between 26 and 34 week's gestation. The capacity to delay delivery 48 h, 7 days, until week 36 or until fetal weight reached 2500 g were the outcome variables assessed. Doppler ultrasound studies were performed on the fetal umbilical artery as control. Results: No significant differences were found in the delay of delivery, but significantly fewer maternal side-effects were found in the nifedipine group. Doppler ultrasound results were similar in both groups. Conclusions: Nifedipine is a valid and well-tolerated alternative among the tocolytic drugs, and apparently does not significantly alter fetal vascular blood flow. (C) 1998 International Federation of Gynecology and Obstetrics.
引用
收藏
页码:239 / 244
页数:6
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