Annexin A5: Shifting from a diagnostic towards a therapeutic realm.

被引：36

作者：

Kenis, H. ^{[1
]}

Hofstra, L. ^{[1
]}

Reutelingsperger, C. P. M. ^{[1
]}

机构：

[1] Cardiovasc Res Inst, NL-6229 ER Maastricht, Netherlands

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2007年 / 64卷 / 22期

关键词：

annexin A5; phosphatidylserine; apoptosis; diagnosis; therapy;

D O I：

10.1007/s00018-007-7297-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The surge in apoptosis research and the discovery of the phosphatidylserine binding properties of annexin A5 have propelled a tremendous interest in cell death detection technologies. In the past years, annexin A5 has evolved from an efficient assay for detection of apoptotic cells in vitro to an in vivo molecular imaging technology with potential clinical use. A second key discovery, the specific internalization properties of annexin A5, has opened the opportunity to use annexin A5 for therapeutic applications. Annexin A5-mediated internalization creates a novel therapeutic platform for targeted drug delivery and cell entry to treat various diseases, including cancer and cardiovascular disease.

引用

页码：2859 / 2862

页数：4

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