Isolation and expression of a novel molecular class D β-lactamase, OXA-61, from Campylobacter jejuni

被引:56
作者
Alfredson, DA [1 ]
Korolik, V [1 ]
机构
[1] Griffith Univ, Inst Glycom, Southport, Qld 4215, Australia
关键词
D O I
10.1128/AAC.49.6.2515-2518.2005
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
A novel β-lactamase gene, bla(OXA-61) from Campylobacter jejuni GC015 was cloned and its nucleotide sequence determined. bla(OXA-61) encodes a protein of 257 amino acids in which the active-site STFK tetrad and conserved class D β-lactamase motifs YGN and KTG were identified. A conserved sequence upstream of bla(OXA-61) is required for expression in Campylobacter.
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页码:2515 / 2518
页数:4
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