De novo nucleases based on HTH and EF-hand chimeras

被引：29

作者：

Welch, JT ^{[1
]}

Sirish, M ^{[1
]}

Lindstrom, KM ^{[1
]}

Franklin, SJ ^{[1
]}

机构：

[1] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA

来源：

INORGANIC CHEMISTRY | 2001年 / 40卷 / 09期

关键词：

D O I：

10.1021/ic0155075

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The reactivity of two de novo peptide chimeras that incorporate sequences from structurally similar parent motifs is reported. The peptides comprise an EF-hand Ca-binding motif and portions of a HTH DNA-binding motif. The Eu(III)-peptide complexes catalyze hydrolysis of phosphate esters and supercoiled DNA.

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页码：1982 / 1984

页数：3

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