Effect of Organic-Phase Solvents on Physicochemical Properties and Cellular Uptake of Astaxanthin Nanodispersions

被引：46

作者：

Anarjan, Navideh ^{[1
]}

Tan, Chin Ping ^{[1
,2
]}

Ling, Tau Chuan ^{[3
]}

Lye, Kwan Liang ^{[4
]}

Malmiri, Hoda Jafarizadeh ^{[5
]}

Nehdi, Imededdine Arbi ^{[2
]}

Cheah, Yoke Kqueen ^{[4
]}

Mirhosseini, Hamed ^{[1
]}

Baharin, Badlishah Sham ^{[1
]}

机构：

[1] Univ Putra Malaysia, Dept Food Technol, Fac Food Sci & Technol, Serdang 43400, Selangor, Malaysia

[2] King Saud Univ, Dept Chem, Coll Sci, Riyadh 11451, Saudi Arabia

[3] Univ Malaya, Inst Biol Sci, Fac Sci, Kuala Lumpur 50603, Malaysia

[4] Univ Putra Malaysia, Dept Biomed Sci, Fac Med & Hlth, Serdang 43400, Selangor, Malaysia

[5] Univ Putra Malaysia, Dept Food Sci, Fac Food Sci & Technol, Serdang 43400, Selangor, Malaysia

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2011年 / 59卷 / 16期

关键词：

astaxanthin nanodispersions; organic-phase solvents; physicochemical characteristics; cellular uptake; BETA-CAROTENE NANODISPERSIONS; IN-VITRO; TRANS-ASTAXANTHIN; PARTICLE-SIZE; STABILITY; CELLS; BIOACCESSIBILITY; ISOMERIZATION; ISOMERS;

D O I：

10.1021/jf201314u

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

A simplex centroid mixture design was used to study the interactions between two chosen solvents, dichloromethane (DCM) and acetone (ACT), as organic phase components in the formation and physicochemical characterization and cellular uptake of astaxanthin nanodispersions produced using precipitation and condensation processes. Full cubic or quadratic regression models with acceptable determination coefficients were obtained for all of the studied responses. Multiple response optimization predicted that the organic phase with 38% (w/w) DCM and 62% (w/w) ACT yielded astaxanthin nanodispersions with the minimum particle size (106 mm), polydispersity index (0.191), and total astaxanthin loss (12.7%, w/w) and the maximum cellular uptake (2981 fmol/cell). Astaxanthin cellular uptake from the produced nanodispersions also showed a good correlation with their particle size distributions and astaxanthin trans/cis isomerization ratios. The absence of significant (p > 0.05) differences between the experimental and predicted values of the response variables confirmed the adequacy of the fitted models.

引用

页码：8733 / 8741

页数：9

共 34 条

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