Electrospun collagen/chitosan nanofibrous membrane as wound dressing

被引：384

作者：

Chen, Jyh-Ping ^{[1
,2
]}

Chang, Gwo-Yun ^{[2
]}

Chen, Jan-Kan ^{[3
]}

机构：

[1] Chang Gung Univ, Dept Chem & Mat Engn, Tao Yuan 333, Taiwan

[2] Chang Gung Univ, Grad Inst Biochem & Biomed Engn, Tao Yuan 333, Taiwan

[3] Chang Gung Univ, Dept Physiol & Pharmacol, Tao Yuan 333, Taiwan

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2008年 / 313卷

关键词：

nanofibers; electrospinning; wound dressing; nanofabrication;

D O I：

10.1016/j.colsurfa.2007.04.129

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Composite nanofibrous membranes (NFM) of type I collagen, chitosan, and polyethylene oxide was fabricated by electrospinning, which could be further crosslinked by glutaraldehyde vapor. The NFM was subject to detailed analysis by scanning electron microscopy, scanning probe microscopy, confocal laser scanning microscopy, Fourier transform infrared spectroscopy, and tensile testing. Nanofiber diameter was found to be 134 +/- 42 nm, which increased to 398 +/- 76 nm after crosslinking. The Young's modulus increased after crosslinking, however, the ultimate tensile strength, tensile strain, and water sorption capability decreased after crosslinking. NFMs showed no cytotoxicity toward growth of 3T3 fibroblasts and had good in vitro biocompatibility. From animal studies, the NFM was better than gauze and commercial collagen sponge wound dressing in wound healing rate. This novel electrospun matrix will have potential as a wound dressing for skin regeneration. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：183 / 188

页数：6

共 17 条

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