IgA and the IgA Fc receptor

被引：233

作者：

van Egmond, M

Damen, CA

van Spriel, AB

Vidarsson, G

van Garderen, E

van de Winkel, JGJ

机构：

[1] Univ Utrecht, Med Ctr, Immunotherapy Lab, Dept Immunol, NL-3584 EA Utrecht, Netherlands

[2] Free Univ Amsterdam, Dept Cell Biol & Immunol, NL-1081 BT Amsterdam, Netherlands

[3] Free Univ Amsterdam, Dept Surg Oncol, NL-1081 BT Amsterdam, Netherlands

[4] Univ Utrecht, Immunotherapy Lab, Dept Immunol, NL-3508 TD Utrecht, Netherlands

[5] Univ Utrecht, Medarex Europe, NL-3508 TD Utrecht, Netherlands

[6] Univ Utrecht, Fac Vet Med, Dept Pathol, NL-3508 TD Utrecht, Netherlands

[7] Univ Utrecht, Med Ctr, Genmab, NL-3584 EA Utrecht, Netherlands

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 04期

关键词：

D O I：

10.1016/S1471-4906(01)01873-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IgA has traditionally been regarded a non-inflammatory antibody. This might indeed be true for secretory IgA (SIgA), which exerts its function at mucosal surfaces where commensal microorganisms and dietary antigens prevail. Serum IgA, however, potently triggers (pro)-inflammatory activity upon binding to the myeloid IgA receptor. Fc alpha RI. Here, new insights in the roles of IgA and Fc alpha RI are addressed and a model integrating the various functions of IgA in immunity is discussed.

引用

收藏

页码：205 / 211

页数：7

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