Insights into the hierarchy of selenium incorporation

被引：49

作者：

Berry, MJ ^{[1
]}

机构：

[1] Univ Hawaii Manoa, Dept Cell & Mol Biol, John A Burns Sch Med, Honolulu, HI 96822 USA

来源：

NATURE GENETICS | 2005年 / 37卷 / 11期

关键词：

D O I：

10.1038/ng1105-1162

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A new study shows that defects in SECIS-binding protein 2 (SBP2), a factor required for incorporation of selenium into proteins, produce alterations in thyroid hormone metabolism in humans but none of the other effects attributed to selenium deficiency or loss of selenoproteins. This finding suggests that SBP2 has a role in distinguishing between selenoproteins whose functions are essential and those with supporting roles in life and health.

引用

页码：1162 / 1163

页数：3

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