Human gene for physical performance

被引：416

作者：

Montgomery, HE

Marshall, R

Hemingway, H

Myerson, S

Clarkson, P

Dollery, C

Hayward, M

Holliman, DE

Jubb, M

World, M

Thomas, EL

Brynes, AE

Saeed, N

Barnard, M

Bell, JD

Prasad, K

Rayson, M

Talmud, PJ

Humphries, SE

机构：

[1] UCL, Cardiovasc Res Ctr, Rayne Inst, London WC1E 6JJ, England

[2] UCL Hosp, London WC1E 6DB, England

[3] DERA, Ctr Human Sci, Farnborough GU14 0LX, Hants, England

[4] Royal Def Med Coll, HMS Dolphin, Gosport PO12 2AB, Hants, England

[5] Imperial Coll Sch Med, MRI Unit, London W12 0HS, England

[6] Univ London St Georges Hosp, Dept Cardiovasc Sci, London SW17 0RE, England

[7] Optimal Performance, Farnham GU9 7EB, Surrey, England

[8] UCL, Ctr Cardiovasc Genet, Rayne Inst, London WC1E 6JJ, England

来源：

NATURE | 1998年 / 393卷 / 6682期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/30374

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A specific genetic factor that strongly influences human physical performance has not so far been reported, but here we show that a polymorphism in the gene encoding angiotensin-converting enzyme does just that. An ‘insertion’ allele of the gene is associated with elite endurance performance among high-altitude mountaineers. Also, after physical training, repetitive weight-lifting is improved eleven-fold in individuals homozygous for the ‘insertion’ allele compared with those homozygous for the ‘deletion’ allele.

引用

页码：221 / 222

页数：2

共 12 条

[1]

BLOOM SR, 1976, J PHYSIOL-LONDON, V258, P1

[2] ANGIOTENSIN-CONVERTING ENZYME IN THE HUMAN HEART - EFFECT OF THE DELETION INSERTION POLYMORPHISM [J].