Negative regulation of antigen receptor signalling in lymphocytes

被引：31

作者：

Plas, DR ^{[1
]}

Thomas, ML ^{[1
]}

机构：

[1] Washington Univ, Howard Hughes Med Inst, Ctr Immunol, Dept Pathol, St Louis, MO 63110 USA

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 1998年 / 76卷 / 08期

关键词：

lymphocytes; T cell receptor; B cell receptor; tyrosine kinases; tyrosine phosphatases;

D O I：

10.1007/s001090050254

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The negative regulation of antigen receptor signal transduction is essential for the maintenance of thresholds for activation in lymphocytes. CD45 and SHP-1 are tyrosine phosphatases that are important in maintaining the proper level of tyrosine phosphorylation. Regulation of the src family of tyrosine kinases is mediated by the coordinated action of the tyrosine kinase Csk and the tyrosine phosphatase CD45. B cell receptor signaling is negatively regulated by the recruitment of SHP-1 to bind the B cell transmembrane proteins CD22 and FcγRIIb1. SHP-1 also functions to negatively regulate T cell receptor signaling by dephosphorylating and inactivating tyrosine kinases.

引用

页码：589 / 595

页数：7

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