COP9 signalosome: A multifunctional regulator of SCF and other cullin-based ubiquitin Ligases

被引：338

作者：

Cope, GA

Deshaies, RJ

机构：

[1] CALTECH, Div Biol, Pasadena, CA 91125 USA

[2] CALTECH, Howard Hughes Med Inst, Pasadena, CA 91125 USA

来源：

CELL | 2003年 / 114卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0092-8674(03)00722-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

COP9 Signalosome (CSN) is a fascinating protein complex whose biochemical and physiological functions are only beginning to be understood. It is conserved throughout eukaryotes and is critical to the proper development of all multicellular organisms in which its function has been explored. Recent work suggests that CSN plays a key role in sustaining the activity of SCF and other cullin-based ubiquitin ligases, which may account for its essential roles in development. Here, we summarize what is known about CSN, and discuss hypotheses for how CSN promotes the activity of SCF ubiquitin ligases.

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页码：663 / 671

页数：9

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