Sunscreen and risk of osteoporosis in the elderly:: A two-year follow-up

被引:23
作者
Farrerons, J
Barnadas, M
López-Navidad, A
Renau, A
Rodríguez, J
Yoldi, B
Alomar, A
机构
[1] Univ Autonoma Barcelona, Hosp Santa Creu & Sant Pau, Dept Internal Med, Mineral Metab Unit, E-08193 Barcelona, Spain
[2] Univ Autonoma Barcelona, Hosp Santa Creu & Sant Pau, Dept Dermatol, E-08193 Barcelona, Spain
[3] Univ Autonoma Barcelona, Hosp Santa Creu & Sant Pau, Dept Biochem, E-08193 Barcelona, Spain
关键词
sunscreen; skin cancer prevention; elderly; osteoporosis;
D O I
10.1159/000051580
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: It has been suggested that the use of sunscreens to prevent skin cancer may put the population at risk of vitamin D deficiency, which in turn may lead to secondary hyperparathyroidism, loss of cortical bone and, ultimately, osteoporotic fractures. Objective: To investigate whether sunscreen SPF15 may lead to loss of bone mass. Methods: We followed 10 sunscreen users and 18 controls over 2 years, including two summers, two winters and a basal period (winter). Bone mass was evaluated each season with dual x-ray absorptiometry. Results: During follow-up, mild fluctuations in bone mass could be seen at Ward's site in both groups, without a definitive pattern. At the final visit, no significant loss of bone mass was observed in sunscreen users or in the control group. We did not observe any significant differences between groups throughout the study. Conclusion: Although the study samples in this work are small, and a slight variation in bone mass may not be detected, in a clinical setting, sunscreen SPF15 protection does not seem to increase the risk of osteoporosis. Copyright (C) 2001 S. Karger AG, Basel.
引用
收藏
页码:27 / 30
页数:4
相关论文
共 13 条
[1]   CALCITRIOL REGULATION OF OSTEOPONTIN EXPRESSION MOUSE EPIDERMAL-CELLS [J].
CHANG, PL ;
RIDALL, AL ;
PRINCE, CW .
ENDOCRINOLOGY, 1994, 135 (03) :863-869
[2]   VITAMIN-D(3) AND CALCIUM TO PREVENT HIP-FRACTURES IN ELDERLY WOMEN [J].
CHAPUY, MC ;
ARLOT, ME ;
DUBOEUF, F ;
BRUN, J ;
CROUZET, B ;
ARNAUD, S ;
DELMAS, PD ;
MEUNIER, PJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (23) :1637-1642
[3]   AN ACTION SPECTRUM FOR UV PHOTOCARCINOGENESIS [J].
COLE, CA ;
FORBES, PD ;
DAVIES, RE .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1986, 43 (03) :275-284
[4]  
DEMAY MB, 1989, J BIOL CHEM, V264, P2279
[5]  
Farrerons J, 1998, BRIT J DERMATOL, V139, P422
[7]   THE PHOTOBIOLOGY OF VITAMIN-D AND ITS CONSEQUENCES FOR HUMANS [J].
HOLICK, MF .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1985, 453 :1-13
[8]   THE EFFECT OF REGULAR SUNSCREEN USE ON VITAMIN-D LEVELS IN AN AUSTRALIAN POPULATION - RESULTS OF A RANDOMIZED CONTROLLED TRIAL [J].
MARKS, R ;
FOLEY, PA ;
JOLLEY, D ;
KNIGHT, KR ;
HARRISON, J ;
THOMPSON, SC .
ARCHIVES OF DERMATOLOGY, 1995, 131 (04) :415-421
[9]   SUNSCREENS SUPPRESS CUTANEOUS VITAMIN-D3 SYNTHESIS [J].
MATSUOKA, LY ;
IDE, L ;
WORTSMAN, J ;
MACLAUGHLIN, JA ;
HOLICK, MF .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1987, 64 (06) :1165-1168
[10]   CHRONIC SUNSCREEN USE DECREASES CIRCULATING CONCENTRATIONS OF 25-HYDROXYVITAMIN-D - A PRELIMINARY-STUDY [J].
MATSUOKA, LY ;
WORTSMAN, J ;
HANIFAN, N ;
HOLICK, MF .
ARCHIVES OF DERMATOLOGY, 1988, 124 (12) :1802-1804