N-Methylpyrrolidin-2-one hydrotribromide (MPHT) a mild reagent for selective bromination of carbonyl compounds:: synthesis of substituted 2-bromo-1-naphtols

被引：54

作者：

Bekaert, A ^{[1
]}

Provot, O ^{[1
]}

Rasolojaona, O ^{[1
]}

Alami, M ^{[1
]}

Brion, JD ^{[1
]}

机构：

[1] Univ Paris Sud, Fac Pharm, Chim Therapeut Lab, BioCIS CNRS UMR 8076, F-92296 Chatenay Malabry, France

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 24期

关键词：

halogenation; MPHT; 1-tetralones; 2-bromo-1-naphtols;

D O I：

10.1016/j.tetlet.2005.04.049

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of the N-methylpyrrolidin-2-one hydrotribromide complex (MPHT) with substituted-1-tetralones has been investigated. This safety reagent proved to be successful for selective alpha,alpha-dibromination of tetralones. Moreover, under base-free conditions, several 2-bromo-1-naphtols were obtained from tetralones in a 'one pot' sequence in good to excellent yields. (c) 2005 Published by Elsevier Ltd.

引用

页码：4187 / 4191

页数：5

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