Efficacy of pneumococcal conjugate vaccine in children

被引:6
作者
Adam, D
Scholz, H
机构
[1] Klinikum Buch, Inst Infektiol Mikrobiol & Hyg, Berlin, Germany
[2] Univ Munich, Dr von Haunersches Kinderspital, Abt Antimikrobielle Therapie, Munich, Germany
来源
KLINISCHE PADIATRIE | 2001年 / 213卷 / 03期
关键词
vaccination; pneumococci; meningitis; pneumonia; otitis media;
D O I
10.1055/s-2001-15860
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Streptococcus pneumoniae is a common cause of meningitis, sepsis, pneumonia, acute otitis media, and sinusitis in children. Children younger than 24 months have the highest rates of invasive pneumococcal infections (Germany 1997-1999: 19.5/100000/year). Pneumococcal infections cause in Germany 220-250 cases of meningitis, about 50000 of pneumonia (children younger than 5 years) and more than 1 million cases of otitis media (children) annually. The case-fatality rate for invasive pneumococcal diseases is high (1997-1999 5.5%, meningitis 8.3%). 20-30% of survivors from meningitis suffer from CNS-related sequelea. In children up to 2 years vaccination with the heptavalent pneumococcal conjugate vaccine can reduce invasive pneumococcal diseases by about 80% and otitis media and recurrent otitis media by 6% and 9-16%, respectively. Due to the increased risk of pneumococcal infections in the first two years of live all children of this age group should be vaccinated. The high rate of resistance of pneumococci against macrolides in Germany, the high rate of non-licensed antibiotics in infants and the inefficacy of the 23-valent vaccine in children younger than 2 years makes the new vaccine to a necessary alternative.
引用
收藏
页码:109 / 113
页数:5
相关论文
共 18 条
  • [1] Abramson JS, 2000, PEDIATRICS, V106, P367, DOI 10.1542/peds.106.2.367
  • [2] Abramson JS, 2000, PEDIATRICS, V106, P362
  • [3] Short-course antibiotic treatment of 4782 culture-proven cases of group A streptococcal tonsillopharyngitis and incidence of poststreptococcal sequelae
    Adam, D
    Scholz, H
    Helmerking, M
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (02) : 509 - 516
  • [4] [Anonymous], 2000, MMWR Recomm Rep, V49, P1
  • [5] Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children
    Black, S
    Shinefield, H
    Fireman, B
    Lewis, E
    Ray, P
    Hansen, JR
    Elvin, L
    Ensor, KM
    Hackell, J
    Siber, G
    Malinoski, F
    Madore, D
    Chang, I
    Kohberger, R
    Watson, W
    Austrian, R
    Edwards, K
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2000, 19 (03) : 187 - 195
  • [6] Colonization with penicillin-nonsusceptible Streptococcus pneumoniae in urban and rural child-care centers
    Boken, DJ
    Chartrand, SA
    Moland, ES
    Goering, RV
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1996, 15 (08) : 667 - 672
  • [7] Carriage of multidrug-resistant Streptococcus pneumoniae and impact of chemoprophylaxis during an outbreak of meningitis at a day care center
    Craig, AS
    Erwin, PC
    Schaffner, W
    Elliott, JA
    Moore, WL
    Ussery, XT
    Patterson, L
    Dake, AD
    Hannah, SG
    Butler, JC
    [J]. CLINICAL INFECTIOUS DISEASES, 1999, 29 (05) : 1257 - 1264
  • [8] Immunogenicity of pneumococcal conjugate vaccines
    Eskola, J
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2000, 19 (04) : 388 - 393
  • [9] Efficacy of a pneumococcal conjugate vaccine against acute otitis media
    Eskola, J
    Kilpi, T
    Palmu, A
    Jokinen, J
    Haapakoski, J
    Herva, E
    Takala, A
    Käyhty, H
    Karma, P
    Kohberger, R
    Siber, G
    Mäkela, PH
    Lockhart, S
    Ecrola, M
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (06) : 403 - 409
  • [10] Marked differences in pneumococcal carriage and resistance patterns between day care centers located within a small area
    Givon-Lavi, N
    Dagan, R
    Fraser, D
    Yagupsky, P
    Porat, N
    [J]. CLINICAL INFECTIOUS DISEASES, 1999, 29 (05) : 1274 - 1280