Metabolic and immunogical features of the failing islet-transplanted patient

被引：19

作者：

Fiorina, Paolo ^{[1
,2
]}

Vergani, Andrea ^{[1
,2
]}

Petrelli, Alessandra ^{[1
]}

D'Addio, Francesca ^{[2
]}

Monti, Lucilla ^{[1
]}

Abdi, Reza ^{[2
]}

Bosi, Emanuele ^{[1
]}

Maffi, Paola ^{[1
]}

Secchi, Antonio ^{[1
,3
]}

机构：

[1] Ist Sci San Raffaele, Dept Med, I-20132 Milan, Italy

[2] Brigham & Womens Hosp, Childrens Hosp, Boston, MA 02115 USA

[3] Univ Vita & Salute San Raffaele, Milan, Italy

来源：

DIABETES CARE | 2008年 / 31卷 / 03期

关键词：

D O I：

10.2337/dc07-1831

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

OBJECTIVE - This retrospective study was designed to identify metabolic and immune predictors of early islet allograft failure. RESEARCH DESIGN AND METHODS - We measured several metabolic and immunological markers at the time of pretransplant and several time points posttransplantation in 17 patients with long-term functioning graft (long fx) and 20 patients with short-term functioning graft (short fx). RESULTS - The short fx group showed higher insulin resistance, altered proinsulin processing, lower soluble interleukin-2 receptor (sIL-2r) (marker of T-cell activation), and higher soluble FasL (marker of apoptosis) during the entire follow-up, particularly at time of failure. CONCLUSIONS- Patients who experienced an early failure of islet allograft showed specific metabolic and immunological signs long before islet failure.

引用

页码：436 / 438

页数：3

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