Epigenetic inactivation of the RASSF1A tumour suppressor gene in ependymoma

被引：31

作者：

Hamilton, DW ^{[1
]}

Lusher, ME ^{[1
]}

Lindsey, JC ^{[1
]}

Ellison, DW ^{[1
]}

Clifford, SC ^{[1
]}

机构：

[1] Newcastle Univ, Sch Med, No Inst Canc Res, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

CANCER LETTERS | 2005年 / 227卷 / 01期

关键词：

ependymoma; RASSF1A; hypermethylation;

D O I：

10.1016/j.canlet.2004.11.044

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To investigate the role of aberrant epigenetic events in ependymoma and identify critical genes in its pathogenesis, the methylation status of nine tumour suppressor genes (TSGs: p14(ARF), p15(INK4B), p,16(INK4A), CASP8, MGMT, TIMP3, TP73, RB1 and RASSF1A) was assessed. Extensive hypermethylation across the RASSF1A CpG island was detected frequently in ependymomas of all clinical and pathological disease subtypes (86% of cases, n = 35), but not in non-neoplastic brain tissues (n = 6). Less frequent methylation was observed for CASP8, MGMT and TP73 (5-20%). The remaining TSGs showed no evidence of methylation. RASSF1A hypermethylation represents the most common gene-specific defect identified in ependymoma highlighting the importance of its further investigation in this disease. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：75 / 81

页数：7

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