Myocardial relaxin counteracts hypertrophy in hypertensive rats

被引：27

作者：

Dschietzig, T ^{[1
]}

Bartsch, C ^{[1
]}

Kinkel, T ^{[1
]}

Baumann, G ^{[1
]}

Stangl, K ^{[1
]}

机构：

[1] Med Klin S Kardiol Angiol & Pulm, Charite Berlin, D-10117 Berlin, Germany

来源：

RELAXIN AND RELATED PEPTIDES: FOURTH INTERNATIONAL CONFERENCE | 2005年 / 1041卷

关键词：

hypertension; hypertrophy; ERK kinases; myocardium; cardiomyocytes;

D O I：

10.1196/annals.1282.066

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Current findings in male relaxin knockout mice indicate antifibrotic and positive lusitropic actions of relaxin on the myocardium. We investigated in 12-month-old male spontaneously hypertensive rats (SHR) and age-matched male Wistar-Kyoto rats (WKY) whether RLX shows antihypertrophic actions as well. SHR showed left heart hypertrophy and a selective elevation of left atrial and ventricular relaxin peptide which inversely correlated with the degree of hypertrophy. In adult rat cardiomyocytes, relaxin blunted phenylephrine-induced hypertrophy by inhibiting activated ERK-1/2 kinases. In conclusion, endogenous myocardial relaxin, upregulated in left heart hypertrophy, exerts antihypertrophic effects by inhibition of activated ERK-1/2 kinases.

引用

页码：441 / 443

页数：3