Factors predicting clinically significant fatigue in women following treatment for primary breast cancer

被引:75
作者
Gerber, Lynn H. [1 ,2 ,6 ]
Stout, Nicole [3 ]
McGarvey, Charles [4 ]
Soballe, Peter [3 ]
Shieh, Ching-yi [6 ]
Diao, Guoqing [2 ]
Springer, Barbara A. [7 ]
Pfalzer, Lucinda A. [5 ]
机构
[1] George Mason Univ, Ctr Study Chron Illness & Disabil, Fairfax, VA 22030 USA
[2] George Mason Univ, Fairfax, VA 22030 USA
[3] Natl Naval Med Ctr, Bethesda, MD USA
[4] CLM Consulting, Rockville, MD USA
[5] Univ Michigan, Flint, MI 48503 USA
[6] NIH, Bethesda, MD 20892 USA
[7] Off Surg Gen, Rockville, MD USA
基金
美国国家卫生研究院;
关键词
Breast cancer; Fatigue; Rehabilitation; Function; QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; ADJUVANT CHEMOTHERAPY; EXERCISE; SLEEP; SURVIVORS; PREVALENCE; DIAGNOSIS; VALIDITY; INSULIN;
D O I
10.1007/s00520-010-0986-7
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cancer-related fatigue is common, complex, and distressing. It affects 70-100% of patients receiving chemotherapy and a significant number who have completed their treatments. We assessed a number of variables in women newly diagnosed with primary breast cancer (BrCa) to determine whether biological and/or functional measures are likely to be associated with the development of clinically significant fatigue (CSF). Two hundred twenty-three women participated in a study designed to document the impact of the diagnosis and treatment of primary breast cancer on function. Forty-four had complete data on all variables of interest at the time of confirmed diagnosis but prior to treatment (baseline) and a parts per thousand yen9 months post-diagnosis. Objective measures and descriptive variables included history, physical examination, limb volume, hemoglobin, white blood cell count, and glucose. Patient-reported outcomes included a verbal numerical rating of fatigue (0-10, a score of a parts per thousand yen4 was CSF), five subscales of the SF-36, Physical Activity Survey, and Sleep Questionnaire. At baseline, the entire cohort (n = 223) and the subset (n = 44) were not significantly different for demographic, biological, and self-reported data, except for younger age (p = 0.03) and ER+ (p = 0.01). Forty-five percent had body mass index (BMI) a parts per thousand yenaEuro parts per thousand 25, 52% were post-menopause, and 52% received modified radical mastectomy, 39% lumpectomy, 52% chemotherapy, 68% radiation, and 86% hormonal therapy. Number of patients with CSF increased from 1 at baseline to 11 at a parts per thousand yen9 months of follow-up. CSF at a parts per thousand yen9 months significantly correlated with BMI a parts per thousand yenaEuro parts per thousand 25, abnormal white blood cell count, and increase in limb volume and inversely correlated with vigorous activity and physical function (p < 0.05). Fatigue increases significantly following the treatment of BrCa. Predictors of CSF include high BMI and WBC count, increase in limb volume, and low level of physical activity. These are remediable.
引用
收藏
页码:1581 / 1591
页数:11
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