NFAT signaling in vertebrate development

被引：173

作者：

Graef, IA

Chen, F

Crabtree, GR ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2001年 / 11卷 / 05期

关键词：

D O I：

10.1016/S0959-437X(00)00225-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

NFATc proteins transduce Ca2+ signals to the nucleus and then pair with other proteins on DNA to generate NFAT complexes that activate transcription in response to both electrical and tyrosine kinase signaling. The four NFATc genes arose at the origin of vertebrates, implying that they have evolved for the development of vertebrate-specific functions, such as a complex nervous system, a recombinational immune system, and a vascular system with a complex heart. These speculations are borne out by studies of mice with null mutations in the different family members.

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页码：505 / 512

页数：8

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