Extensive diversity of Ig-superfamily proteins in the immune system of insects

被引：522

作者：

Watson, FL ^{[1
]}

Püttmann-Holgado, R ^{[1
]}

Thomas, F ^{[1
]}

Lamar, DL ^{[1
]}

Hughes, M ^{[1
]}

Kondo, M ^{[1
]}

Rebel, VI ^{[1
]}

Schmucker, D ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Biol,Dept Neurobiol, Boston, MA 02115 USA

来源：

SCIENCE | 2005年 / 309卷 / 5742期

关键词：

D O I：

10.1126/science.1116887

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The extensive somatic diversification of immune receptors is a hallmark of higher vertebrates. However, whether molecular diversity contributes to immune protection in invertebrates is unknown. We present evidence that Drosophila immune-competent cells have the potential to express more than 18,000 isoforms of the immunoglobulin (Ig)-superfamily receptor Down syndrome cell adhesion molecule (Dscam). Secreted protein isoforms of Dscam were detected in the hemolymph, and hemocyte-specific loss of Dscam impaired the efficiency of phagocytic uptake of bacteria, possibly due to reduced bacteria[ binding. Importantly, the molecular diversity of Dscam transcripts generated through a mechanism of alternative splicing is highly conserved across major insect orders, suggesting an unsuspected molecular complexity of the innate immune system of insects.

引用

页码：1874 / 1878

页数：5

共 23 条

[1] Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury [J].