The chromosomal duplication model of the major histocompatibility complex

被引：97

作者：

Kasahara, M

机构：

[1] Grad Univ Adv Studies, Dept Biosyst Sci, Hayama 2400193, Japan

[2] Japan Sci & Technol Corp, CREST, Hayama, Japan

来源：

IMMUNOLOGICAL REVIEWS | 1999年 / 167卷

关键词：

D O I：

10.1111/j.1600-065X.1999.tb01379.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The major histocompatibility complex (MHC) is a genetic region that has been extensively studied by immunologists, molecular biologists, and evolutionary biologists. Nevertheless, our knowledge of how the MHC acquired its present-day organization is quite Limited. The recent discovery that the mammalian genome contains regions paralogous to the MHC has led us to the proposal that the MHC region of jawed vertebrates arose as a result of ancient chromosomal duplications. Here, I review the current status of this proposal.

引用

页码：17 / 32

页数：16

共 121 条

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