Searching for unique endophenotypes for schizophrenia and bipolar disorder within neural circuits and their molecular regulatory mechanisms

被引：36

作者：

Benes, Francine M.

机构：

[1] McLean Hosp, Program Struct & Mol Neurosci, Belmont, MA 02478 USA

[2] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02115 USA

来源：

SCHIZOPHRENIA BULLETIN | 2007年 / 33卷 / 04期

关键词：

apoptosis; L-type calcium channel; antioxidation genes; cell viability; gene expression profiling;

D O I：

10.1093/schbul/sbm064

中图分类号：

R749 [精神病学];

学科分类号：

100205 [精神病与精神卫生学];

摘要：

The endophenotype is a construct that has utility for the study of postmortem brains from patients with psychotic disorders. By identifying networks of genes that show changes in expression within specific neuronal populations implicated in the pathophysiology of schizophrenia and bipolar disorder, it may be possible to move toward understanding these disorders at the cellular and molecular levels. The ultimate goal is to characterize their respective underlying genotypes.

引用

页码：932 / 936

页数：5

共 33 条

[1]

GENE-EXPRESSION FOR GLUTAMIC-ACID DECARBOXYLASE IS REDUCED WITHOUT LOSS OF NEURONS IN PREFRONTAL CORTEX OF SCHIZOPHRENICS [J].