Rare case of Helicobacter pylori-positive multiorgan IgG4-related disease and gastric cancer

被引：12

作者：

Li, Min ^{[1
]}

Zhou, Qiang ^{[1
]}

Yang, Kun ^{[1
]}

Brigstock, David R. ^{[2
,3
]}

Zhang, Lu ^{[1
]}

Xiu, Ming ^{[1
]}

Sun, Li ^{[1
]}

Gao, Run-Ping ^{[1
]}

机构：

[1] Jilin Univ, Hosp 1, Dept Hepat Biliary Pancreat Med, Changchun 130021, Jilin Province, Peoples R China

[2] Nationwide Childrens Hosp, Res Inst, Columbus, OH 43205 USA

[3] Ohio State Univ, Div Pediat Surg, Dept Surg, Columbus, OH 43205 USA

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2015年 / 21卷 / 11期

关键词：

IgG4-related disease; Helicobacter pylori; Type 1 autoimmune pancreatitis; Sclerosing cholecystocholangitis; Gastric cancer; AUTOIMMUNE PANCREATITIS; CARBONIC-ANHYDRASE; SERUM IGG4; PATHOGENESIS; DIAGNOSIS; INFECTION;

D O I：

10.3748/wjg.v21.i11.3429

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

A 61-year-old male from Northeast China presented with a 2-mo history of abdominal distension, pruritus and jaundice. Laboratory testing revealed an elevated showed a typical feature of autoimmune pancreatitis (AIP) and cholecystocholangitis. Early gastric cancer was incidentally discovered when endoscopic untrasound-guided fine needle aspiration (EUSFNA) of the pancreas was carried out. The patient underwent radical subtotal gastrectomy for gastric cancer combined with cholecystectomy. Helicobacter pylori (H. pylori) and IgG4-positive plasmacytes were detected in gastric cancer tissue, pancreatic EUSFNA sample and resected gallbladder specimen by immunohistochemistry. The patient was diagnosed with H. pylori-positive IgG4-related AIP and sclerosing cholecystocholangitis as well as H. pylori-positive gastric cancer. He responded well to steroid therapy and remains healthy with no signs of recurrence at one year follow-up. We speculate that H. pylori might act as a trigger via direct or indirect action in the initiation of onset of gastric cancer and multiorgan IgG4-related disease.

引用

页码：3429 / 3434

页数：6

共 21 条

[1]

Helicobacter pylori-Induced Chronic Gastritis and Assessing Risks for Gastric Cancer [J].