Brain studies of mouse models for neurogenetic disorders using in vivo magnetic resonance imaging (MRI)

被引：19

作者：

Kooy, RF

Verhoye, M

Lemmon, V

Van Der Linden, A

机构：

[1] Univ Antwerp, Dept Med Genet, B-2610 Antwerp, Belgium

[2] Univ Antwerp, Bioimaging Lab, B-2610 Antwerp, Belgium

[3] Case Western Reserve Univ, Dept Neurosci, Cleveland, OH 44106 USA

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 2001年 / 9卷 / 03期

关键词：

magnetic resonance imaging; fragile X syndrome; X-linked hydrocephalus; knockout mouse; mental retardation; brain structure;

D O I：

10.1038/sj.ejhg.5200606

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Magnetic resonance imaging (MRI) is a technique commonly used to detect neural abnormalities in routine clinical practice. It is perhaps less well known that the technique can be adapted to measure various anatomical and physiological features of small laboratory rodents. This review focuses on the potential of the MRI technique to image the brain of (transgenic) mouse models for neurological diseases, and aims to introduce these exciting new technological developments to the non-specialist reader.

引用

页码：153 / 159

页数：7

共 26 条

[1]

BAKKER CE, 1994, CELL, V78, P23

[2] High-resolution magnetic resonance angiography of the mouse brain: Application to murine focal cerebral ischemia models [J].