Extracts of Halenia elliptica exhibit antioxidant properties in vitro and in vivo

被引：70

作者：

Huang, Bo ^{[1
]}

Ke, Haibin ^{[1
]}

He, Jingsheng ^{[1
]}

Ban, Xiaoquan ^{[1
]}

Zeng, Hong ^{[1
]}

Wang, Youwei ^{[1
]}

机构：

[1] Wuhan Univ, Coll Pharm, Inst TCM & Nat Prod, Wuhan 430071, Peoples R China

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2011年 / 49卷 / 01期

关键词：

Halenia elliptica; Antioxidant activity; Radical-scavenging activity; Lipid peroxidation; In vitro and in vivo systems; RADICAL-SCAVENGING ACTIVITY; LIPID-PEROXIDATION; ACID;

D O I：

10.1016/j.fct.2010.10.015

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

The antioxidant properties of different extracts of Halenia elliptica was investigated by employing various established in vitro systems. The results showed that various extracts possessed strong antioxidant activity in vitro, and the 70% methanol extract (ME) had the strongest antioxidant activity. Based on our in vitro results, ME was used for investigating the antioxidant properties of H. elliptica in vivo. The liver and kidney of CCl4-intoxicated animals exhibited a significant decrease in superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) levels. Additionally, these organs exhibited a significant increase in the level of malondialdehyde (MDA). These changes were significantly reversed, in a dose-dependent manner, after treatment with ME and the standard treatment Vitamin E. Thus, it may be concluded that the ME possesses potent antioxidant properties, and might be valuable natural source of antioxidants that could be applicable to both the medical and food industries. (C) 2010 Elsevier Ltd. An rights reserved.

引用

页码：185 / 190

页数：6

共 39 条

[1]

Ameliorative effect of ajwain extract on hexachlorocyclohexane-induced lipid peroxidation in rat liver [J].