NOD2 gene variants are a risk factor for culture-positive spontaneous bacterial peritonitis and monomicrobial bacterascites in cirrhosis

被引：59

作者：

Bruns, Tony ^{[1
,2
]}

Peter, Jack ^{[1
]}

Reuken, Philipp A. ^{[1
,2
]}

Grabe, Dominik H. ^{[3
]}

Schuldes, Sonja R. ^{[3
]}

Brenmoehl, Julia ^{[1
]}

Schoelmerich, Juergen ^{[3
]}

Wiest, Reiner ^{[3
]}

Stallmach, Andreas ^{[1
,2
]}

机构：

[1] Jena Univ Hosp, Dept Internal Med 2, Div Gastroenterol Hepatol & Infect Dis, Jena, Germany

[2] Integrated Res & Treatment Ctr Sepsis Control & C, Jena, Germany

[3] Regensburg Univ Hosp, Dept Internal Med 1, Regensburg, Germany

来源：

LIVER INTERNATIONAL | 2012年 / 32卷 / 02期

关键词：

bacterascites; bacterial translocation; cirrhosis; mortality; NOD2; gene; spontaneous bacterial peritonitis; CROHNS-DISEASE; FRAMESHIFT MUTATION; ASCITIC FLUID; ASSOCIATION; TRANSLOCATION; SUSCEPTIBILITY; NOD2/CARD15; OVERGROWTH; PREVALENCE; MANAGEMENT;

D O I：

10.1111/j.1478-3231.2011.02561.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Background: Spontaneous bacterial peritonitis (SBP) is considered as result of bacterial translocation from the gastrointestinal lumen to the mesenteric lymph nodes and subsequent circulation. Variants of the NOD2 gene contribute to bacterial translocation and were associated with SBP in a recent study.

引用

页码：223 / 230

页数：8

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