Synthesis of conformationally constrained cyclic peptides using an intramolecular Sonogashira coupling

被引：32

作者：

Balraju, V

Reddy, DS

Periasamy, M

Iqbal, J

机构：

[1] Dr Reddys Labs Ltd, Hyderabad 500049, Andhra Pradesh, India

[2] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 23期

关键词：

D O I：

10.1021/jo051412z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Small peptides having a 3-bromobenzyl group at the C-termini and n-alkynoyl group at the N-termini undergo a smooth copper-free intramolecular Sonogashira coupling reaction to afford the corresponding cyclic peptides in moderate yields. Scope and limitations of this macrocyclization is demonstrated with di-, tri-, and tetrapeptides.

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收藏

页码：9626 / 9628

页数：3

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