The story so far:: Helicobacter pylori and gastric autoimmunity

被引：47

作者：

Bergman, MP

Vandenbroucke-Grauls, CMJE

Appelmelk, BJ

D'Elios, M

Amedei, A

Azzurri, A

Benagiano, N

Del Prete, G

机构：

[1] VU Med Ctr, Dept Med Microbiol & Infect Control, Amsterdam, Netherlands

[2] Univ Florence, Dept Internal Med & Immunoallergol, Florence, Italy

来源：

INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2005年 / 24卷 / 1-2期

关键词：

Helicobacter pylori; antiparietal cell autoantibodies; H+; K+-ATPase; autoimmune gastritis; Th1; cells; cytokines; Fas; apoptosis;

D O I：

10.1080/08830180590884648

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The gastric mucosal pathogen Helicobacter pylori induces autoantibodies directed against the gastric proton pump H+,K+-ATPase in 20-30% of infected patients. The presence of these autoantibodies is associated with severity of gastritis, increased atrophy, and apoptosis in the corpus mucosa, and patients with these autoantibodies infected with H. pylori display histopathological and clinical features that are similar to those of autoimmune gastritis (AIG). This review will focus on the T helper cell responses, cytokines, and adhesion molecules involved in corpus mucosal atrophy in chronic H. pylori gastritis and in AIG, and the role of H. pylori in the onset of AIG.

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页码：63 / 91

页数：29

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