The synthesis of the αvβ3 integrin receptor ligand [125I]L-775,219.

被引：10

作者：

Hamill, TG

Duggan, ME

Perkins, JJ

机构：

[1] Merck Res Labs, Dept Pharmacol, West Point, PA 19486 USA

[2] Merck Res Labs, Dept Med Chem, West Point, PA 19486 USA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2001年 / 44卷 / 01期

关键词：

iodine-125; vitronectin; alpha(V)beta(3) integrin; radioiodination;

D O I：

10.1002/jlcr.432

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The alpha (v)beta (3) integrin receptor ligand [I-125]L-775,219, 1c, was synthesized for use in an in vitro receptor binding assay with high specific activity (>1500 Ci/mmol) and a radiochemical yield of 15-20%. Conversion of iodide 1b to the corresponding aryl trimethylstannane 2, followed by radioiodination using (NaI)-I-125/iodobead gave 1c.

引用

页码：55 / 59

页数：5

共 8 条

[1]

CHAMBERS TJ, 1986, BONE MINER, V1, P127

[2] Antibody to beta(3) integrin inhibits osteoclast-mediated bone resorption in the thyroparathyroidectomized rat [J].