Evidence that the PTH receptor binding site on PTHrP(1-34) can hinge at ARG19/ARG20

被引：12

作者：

Barden, JA

Kemp, BE

机构：

[1] UNIV SYDNEY,DEPT ANAT & HISTOL,SYDNEY,NSW 2006,AUSTRALIA

[2] ST VINCENTS INST MED RES,MELBOURNE 3065,AUSTRALIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 220卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1006/bbrc.1996.0390

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of the biologically-active mutant of human parathyroid hormone related protein (residues 1-34) containing an Ala substituted for a His in position 9 reveals two segments of helix extending from Glu4 to Lys13 and from Phe22 to Ala34, with a reverse turn from Gln16 to Arg19. The C-terminal region contains the bulk of the PTH receptor binding site in an amphipathic helix and is capable of hinging at Arg19/Arg20. The region of the molecule containing full antagonist properties is thus confined to the C-terminal helix. (C) 1996 Academic Press, Inc.

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收藏

页码：431 / 436

页数：6

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