Taurine increases cell proliferation and generates an increase in [Mg2+]i accompanied by ERK 1/2 activation in human osteoblast cells

被引：42

作者：

Jeon, Seol-Hee ^{[1
,3
]}

Lee, Mun-Young ^{[1
]}

Kim, Shang-Jin ^{[1
]}

Joe, Sung-Gun ^{[1
]}

Kim, Gi-Beum ^{[1
]}

Kim, In-Shik ^{[2
]}

Kim, Nam-Soo ^{[2
]}

Hong, Chul-Un ^{[3
,4
]}

Kim, Sung-Zoo ^{[3
]}

Kim, Jin-Shang ^{[1
,2
]}

Kang, Hyung-Sub ^{[1
,2
,3
]}

机构：

[1] Chonbuk Natl Univ, Coll Vet Med, Dept Pharmacol & Toxicol, Jeonju 561756, South Korea

[2] Chonbuk Natl Univ, Biosafety Res Inst, Jeonju 561756, South Korea

[3] Chonbuk Natl Univ, Ctr Healthcare Technol Dev, Jeonju 561756, South Korea

[4] Chonbuk Natl Univ, Coll Engn, Div Bion & Bioinformat, Jeonju 561756, South Korea

来源：

FEBS LETTERS | 2007年 / 581卷 / 30期

关键词：

taurine; intracellular magnesium; ERK; 1/2; human osteoblast cell; PD98059;

D O I：

10.1016/j.febslet.2007.11.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Taurine has been reported to influence bone metabolism, and its specific transport system, the taurine transporter, is expressed in osteoblasts. The mean [Mg2+]i was 0.51 +/- 0.01 mM in normal culture media. Taurine caused an increase in [Mg2+] i by 0.72 +/- 0.04 mM in human osteoblast (HOB) cells. This increment in [Mg2+]i was inhibited significantly by PD98059, nifedipine, lidocaine, and imipramine. Taurine was also shown to stimulate the activation of ERK 1/2. This taurine-stimulated ERK 1/2 activation was inhibited by PD98059. In the present study, taurine was shown to increase cell proliferation and generate an increase in [Mg2+] i accompanied by ERK 1/2 activation in HOB cells. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：5929 / 5934

页数：6

共 37 条

[1] EVIDENCE FOR PARATHYROID FAILURE IN MAGNESIUM DEFICIENCY [J].

ANAST, CS ;

BURNS, TW ;

MOHS, JM ;

KAPLAN, SS .

SCIENCE, 1972, 177 (4049) :606-&

[2] EFFECT OF SHORT-TERM HYPOMAGNESEMIA ON THE CHEMICAL AND MECHANICAL-PROPERTIES OF RAT BONE [J].

BOSKEY, AL ;

RIMNAC, CM ;

BANSAL, M ;

FEDERMAN, M ;

LIAN, J ;

BOYAN, BD .

JOURNAL OF ORTHOPAEDIC RESEARCH, 1992, 10 (06) :774-783

[3] OSTEOCALCIN AND ITS MESSAGE - RELATIONSHIP TO BONE-HISTOLOGY IN MAGNESIUM-DEPRIVED RATS [J].

CARPENTER, TO ;

MACKOWIAK, SJ ;

TROIANO, N ;

GUNDBERG, CM .

AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (01) :E107-E114

[4] Differential localization and operation of distinct Mg2+ transporters in apical and basolateral sides of rat liver plasma membrane [J].

Cefaratti, C ;

Romani, A ;

Scarpa, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (06) :3772-3780

[5]

FERAY JC, 1987, J BIOL CHEM, V262, P5763

[6]

FERAY JC, 1988, N-S ARCH PHARMACOL, V338, P332

[7] MAGNESIUM TRANSPORT IN FERRET RED-CELLS [J].

FLATMAN, PW ;

SMITH, LM .

JOURNAL OF PHYSIOLOGY-LONDON, 1990, 431 :11-25

[8] MECHANISMS OF MAGNESIUM TRANSPORT [J].

FLATMAN, PW .

ANNUAL REVIEW OF PHYSIOLOGY, 1991, 53 :259-271

[9]

GOYTAIN A, 2005, BMC GENOMICS, V10, P1471

[10] CHARACTERIZATION OF MG-2+ EFFLUX FROM HUMAN, RAT AND CHICKEN ERYTHROCYTES [J].

GUNTHER, T ;

VORMANN, J .

FEBS LETTERS, 1989, 250 (02) :633-637

← 1 2 3 4 →