Retinal prosthesis

被引:318
作者
Weiland, JD [2 ]
Liu, WT
Humayun, MS
机构
[1] Univ So Calif, Viterbi Sch Engn, Dept Biomed Engn, Los Angeles, CA 90089 USA
[2] Univ So Calif, Keck Sch Med, Dept Ophthalmol, Doheny Retina Inst, Los Angeles, CA 90089 USA
[3] Univ Calif Santa Cruz, Baskin Sch Engn, Dept Elect Engn, Santa Cruz, CA 95064 USA
关键词
visual rehabilitation; retinal degeneration; electrical stimulation; implantable medical device; artificial vision;
D O I
10.1146/annurev.bioeng.7.060804.100435
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Retinal prostheses represent the best near-term hope for individuals with incurable, blinding diseases of the outer retina. On the basis of the electrical activation of nerves, prototype retinal prostheses have been tested in blind humans and have demonstrated the capability to elicit the sensation of light and to give test subjects the ability to detect motion. To improve the visual function in implant recipients, a more sophisticated device is required. Simulations suggest that 600-1000 pixels will be required to provide visual function such as face recognition and reading. State-of-the-art implantable stimulator technology cannot produce such a device, which mandates the advancement of the state of the art in areas such as analog microelectronics, wireless power and data transfer, packaging, and stimulating electrodes.
引用
收藏
页码:361 / 401
页数:45
相关论文
共 165 条
[1]   BATCH-FABRICATED THIN-FILM ELECTRODES FOR STIMULATION OF THE CENTRAL AUDITORY-SYSTEM [J].
ANDERSON, DJ ;
NAJAFI, K ;
TANGHE, SJ ;
EVANS, DA ;
LEVY, KL ;
HETKE, JF ;
XUE, XL ;
ZAPPIA, JJ ;
WISE, KD .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1989, 36 (07) :693-704
[2]  
[Anonymous], 1999, C951 IEEE
[3]  
[Anonymous], 1996, P 18 ANN INT C IEEE
[4]  
*ANSI, 2004, Z1361 ANSI
[5]  
BECKER M, 1999, IEEE NEURAL NETWORKS, V1, P192
[6]   CHARGE INJECTION LIMITS OF ACTIVATED IRIDIUM OXIDE ELECTRODES WITH 0.2MS PULSES IN BICARBONATE BUFFERED SALINE [J].
BEEBE, X ;
ROSE, TL .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1988, 35 (06) :494-495
[7]  
BERSON EL, 1993, INVEST OPHTH VIS SCI, V34, P1659
[8]   RETINAL DEGENERATION IN THE RD MOUSE IS CAUSED BY A DEFECT IN THE BETA-SUBUNIT OF ROD CGMP-PHOSPHODIESTERASE [J].
BOWES, C ;
LI, TS ;
DANCIGER, M ;
BAXTER, LC ;
APPLEBURY, ML ;
FARBER, DB .
NATURE, 1990, 347 (6294) :677-680
[9]  
BRINDLEY GS, 1974, T AM ACAD OPHTHALMOL, V78, pO741
[10]  
Bron AJ., 1997, WOLFFS ANATOMY EYE O, V8th