Ornithine decarboxylase antizyme: A novel type of regulatory protein

被引：183

作者：

Hayashi, S

Murakami, Y

Matsufuji, S

机构：

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1996年 / 21卷 / 01期

关键词：

D O I：

10.1016/0968-0004(96)80882-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antizyme plays an important regulatory role in the synthesis of ornithine decarboxylase (ODC), a key enzyme of polyamine synthesis in higher animals. As well as inactivating polyamine uptake, antizyme is induced by polyamine-enhanced translational frameshifting, and binds to ODC, accelerating its ATP-dependent degradation, a process catalysed by the 26S proteasome.

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页码：27 / 30

页数：4

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