Reversible inactivation of subcortical sites by drug injection

被引:77
作者
Malpeli, JG [1 ]
机构
[1] Univ Illinois, Dept Psychol, Champaign, IL 61820 USA
关键词
reversible inactivation; drug injections; lidocaine; cobalt; muscimol; GABA;
D O I
10.1016/S0165-0270(98)00161-7
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Reversible inactivation of subcortical targets by means of drug injections has been a powerful tool for revealing the contributions of discrete brain structures to behavior and the functional organization of the brain. This paper is intended to provide practical advice on this approach, including the choice of drug, means of delivering drugs, strategies for evaluating the action of injected drugs, and the application of this method to experiments with awake animals. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:119 / 128
页数:10
相关论文
共 31 条
[1]  
DEADWYLER SA, 1979, ELECTROENCEPHALOGR C, V47, P725
[2]   STIMULATION OR BLOCKADE OF THE DORSAL NUCLEUS OF THE LATERAL LEMNISCUS ALTERS BINAURAL AND TONIC INHIBITION IN CONTRALATERAL INFERIOR COLLICULUS NEURONS [J].
FAINGOLD, CL ;
ANDERSON, CAB ;
RANDALL, ME .
HEARING RESEARCH, 1993, 69 (1-2) :98-106
[4]   CALCIUM-CHANNEL [J].
HAGIWARA, S ;
BYERLY, L .
ANNUAL REVIEW OF NEUROSCIENCE, 1981, 4 :69-125
[5]   MODIFICATION OF SACCADIC EYE-MOVEMENTS BY GABA-RELATED SUBSTANCES .1. EFFECT OF MUSCIMOL AND BICUCULLINE IN MONKEY SUPERIOR COLLICULUS [J].
HIKOSAKA, O ;
WURTZ, RH .
JOURNAL OF NEUROPHYSIOLOGY, 1985, 53 (01) :266-291
[6]   Thalamic control of cat area-18 supragranular layers: Simple cells, complex cells, and cells projecting to the lateral suprasylvian visual area [J].
Lee, C ;
Weyand, TG ;
Malpeli, JG .
VISUAL NEUROSCIENCE, 1998, 15 (01) :27-35
[7]   Thalamic control of cat lateral suprasylvian visual area: Relation to patchy association projections from area 18 [J].
Lee, C ;
Weyand, TG ;
Malpeli, JG .
VISUAL NEUROSCIENCE, 1998, 15 (01) :15-25
[8]   POPULATION CODING OF SACCADIC EYE-MOVEMENTS BY NEURONS IN THE SUPERIOR COLLICULUS [J].
LEE, CK ;
ROHRER, WH ;
SPARKS, DL .
NATURE, 1988, 332 (6162) :357-360
[9]   SOMATA-SELECTIVE LESIONS INDUCED BY COBALTOUS CHLORIDE - A PARAMETRIC STUDY [J].
LEE, CK ;
MALPELI, JG .
BRAIN RESEARCH, 1986, 364 (02) :396-399
[10]  
MACDONALD RL, 1994, ANNU REV NEUROSCI, V17, P569, DOI 10.1146/annurev.neuro.17.1.569