Group I mGluR antagonist AIDA protects nigral DA cells from MPTP-induced injury

被引：40

作者：

Aguirre, JA ^{[1
]}

Andbjer, B

González-Barón, S

Hansson, A

Strömberg, I

Agnati, LF

Fuxe, K

机构：

[1] Univ Malaga, Sch Med, Dept Physiol, E-29080 Malaga, Spain

[2] Karolinska Inst, Dept Neurosci, Div Cellular & Mol Neurochem, S-17177 Stockholm, Sweden

[3] Univ Modena, Dept Biomed Sci, I-41100 Modena, Italy

来源：

NEUROREPORT | 2001年 / 12卷 / 12期

关键词：

1-aminoindan-1,5-dicarboxylic acid; dopamine; immunocytochemistry; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; mGluR1; mouse; Parkinson's disease; stereology; substantia nigra; tyrosine hydroxylase;

D O I：

10.1097/00001756-200108280-00006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The effects of i.c.v. injection of AIDA, a group I mGluR antagonist, were studied on the nigral DA cells after MPTP-induced injury in the black mouse, using TH immunocytochemistry and unbiased stereology. MPTP reduced the total number of TH-IR neurons by 55.2% and non-TH-IR neurons by 27.5% A 15 min AIDA pre-treatment (10 nmol) selectively counteracted the loss of TH-IR cells caused by MPTP as evaluated 10 days after the insult without changing the total number of nonneuronal cell nuclei. The results suggest that group I mGluR antagonists may have a neuroprotective role against MPTP-induced degeneration of DA neurons and thus probably also against neurodegenerative processes occurring in Parkinson's disease. NeuroReport 12:2615-2617 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：2615 / 2617

页数：3

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