Apoptosis induced by aminoglycosides in LLC-PK1 cells: Comparative study of neomycin, gentamicin, amikacin, and isepamicin using electroporation

被引：12

作者：

Denamur, Sophie ^{[1
]}

Van Barnbeke, Francoise ^{[1
]}

Mingeot-Leclercq, Marie-Paule ^{[1
]}

Tulkens, Paul M. ^{[1
]}

机构：

[1] Catholic Univ Louvain, Unite Pharmacol Cellulaire & Mol, B-1200 Brussels, Belgium

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 06期

关键词：

D O I：

10.1128/AAC.01680-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

Levels of apoptosis induction (4',6'-diamidino-2-phenylindole staining, activation of caspase 3) for amino-glycosides were compared by using renal LLC-PK1 cells. Amikacin caused less apoptosis than gentamicin in incubated cells. In electroporated cells, neomycin B and gentamicin caused apoptosis in the 0.03 to 0.1 mM range, isepamicin required larger concentrations (0.2 mM), and amikacin was without effect.

引用

页码：2236 / 2238

页数：3

共 26 条

[1]

Cisplatin nephrotoxicity [J].

Arany, I ;

Safirstein, RL .

SEMINARS IN NEPHROLOGY, 2003, 23 (05) :460-464

[2]

Choi Kyu Hun, 2000, Korean Journal of Internal Medicine, V15, P218

[3]

Gentamicin-induced apoptosis in renal cell lines and embryonic rat fibroblasts [J].

El Mouedden, M ;

Laurent, G ;

Mingeot-Leclercq, MP ;

Tulkens, PM .

TOXICOLOGICAL SCIENCES, 2000, 56 (01) :229-239

[4]

Apoptosis in renal proximal tubules of rats treated with low doses of aminoglycosides [J].

El Mouedden, M ;

Laurent, G ;

Mingeot-Leclercq, MP ;

Taper, HS ;

Cumps, J ;

Tulkens, PM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (03) :665-675

[5]

Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research [J].

Gehl, J .

ACTA PHYSIOLOGICA SCANDINAVICA, 2003, 177 (04) :437-447

[6]

GILBERT DN, 2005, PRINCIPLES PRACTICE, P328

[7]

COMPARATIVE LOW-DOSE NEPHROTOXICITIES OF GENTAMICIN, TOBRAMYCIN, AND AMIKACIN [J].

HOTTENDORF, GH ;

GORDON, LL .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1980, 18 (01) :176-181

[8]

Tetramethylpyrazine protects rat renal tubular cell apoptosis induced by gentamicin [J].

Juan, Shu-Hui ;

Chen, Cheng-Hsien ;

Hsu, Yung-Ho ;

Hou, Chun-Cheng ;

Chen, Tso-Hsiao ;

Lin, Heng ;

Chu, Yen-Ling ;

Sue, Yuh-Mou .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2007, 22 (03) :732-739

[9]

MECHANISM OF AMINOGLYCOSIDE-INDUCED LYSOSOMAL PHOSPHOLIPIDOSIS - INVITRO AND INVIVO STUDIES WITH GENTAMICIN AND AMIKACIN [J].

LAURENT, G ;

CARLIER, MB ;

ROLLMAN, B ;

VANHOOF, F ;

TULKENS, P .

BIOCHEMICAL PHARMACOLOGY, 1982, 31 (23) :3861-3870

[10]

Bacterial resistance: Origins, epidemiology, and impact [J].

Livermore, DM .

CLINICAL INFECTIOUS DISEASES, 2003, 36 :S11-S23

← 1 2 3 →