Morphine-induced μ-opioid receptor internalization:: A paradox solved in neurons

被引：7

作者：

Beaulieu, JM ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA

来源：

JOURNAL OF NEUROSCIENCE | 2005年 / 25卷 / 44期

关键词：

D O I：

10.1523/JNEUROSCI.3914-05.2005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

引用

页码：10061 / 10063

页数：3

共 7 条

[1] An Akt/β-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior [J].

Beaulieu, JM ;

Sotnikova, TD ;

Marion, S ;

Lefkowitz, RJ ;

Gainetdinov, RR ;

Caron, MG .

CELL, 2005, 122 (02) :261-273

[2] μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence [J].

Bohn, LM ;

Gainetdinov, RR ;

Lin, FT ;

Lefkowitz, RJ ;

Caron, MG .

NATURE, 2000, 408 (6813) :720-723

[3] Enhanced morphine analgesia in mice lacking β-arrestin 2 [J].

Bohn, LM ;

Lefkowitz, RJ ;

Gainetdinov, RR ;

Peppel, K ;

Caron, MG ;

Lin, FT .

SCIENCE, 1999, 286 (5449) :2495-2498

[4] Morphine promotes rapid, arrestin-dependent endocytosis of μ-opioid receptors in striatal neurons [J].

Debic, HH ;

Kim, KA ;

Yu, YJ ;

von Zastrow, M .

JOURNAL OF NEUROSCIENCE, 2005, 25 (34) :7847-7857

[5] Desensitization of G protein-coupled receptors and neuronal functions [J].

Gainetdinov, RR ;

Premont, RT ;

Bohn, LM ;

Lefkowitz, RJ ;

Caron, MG .

ANNUAL REVIEW OF NEUROSCIENCE, 2004, 27 :107-144

[6]

Haberstock-Debic H, 2003, J NEUROSCI, V23, P4324

[7] Functional dissociation of μ opioid receptor signaling and endocytosis:: Implications for the biology of opiate tolerance and addiction [J].

Whistler, JL ;

Chuang, HH ;

Chu, P ;

Jan, LY ;

von Zastrow, M .

NEURON, 1999, 23 (04) :737-746

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