Satellite cells, the engines of muscle repair

被引：351

作者：

Wang, Yu Xin ^{[1
,2
]}

Rudnicki, Michael A. ^{[1
,2
]}

机构：

[1] Ottawa Hosp Res Inst Ottawa, Sprott Ctr Stem Cell Res, Ottawa, ON K1H 8L6, Canada

[2] Univ Ottawa, Dept Cellular & Mol Med, Fac Med, Ottawa, ON K1H 8M5, Canada

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2012年 / 13卷 / 02期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

SKELETAL-MUSCLE; SELF-RENEWAL; STEM-CELLS; MYOGENIC DIFFERENTIATION; OVERLAPPING FUNCTIONS; PROGENITOR CELLS; UP-REGULATION; GENE MYF-5; PAX7; MYOD;

D O I：

10.1038/nrm3265

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Satellite cells are a heterogeneous population of stem and progenitor cells that are required for the growth, maintenance and regeneration of skeletal muscle. The transcription factors paired-box 3 (PAX3) and PAX7 have essential and overlapping roles in myogenesis. PAX3 acts to specify embryonic muscle precursors, whereas PAX7 enforces the satellite cell myogenic programme while maintaining the undifferentiated state. Recent experiments have suggested that PAX7 is dispensable in adult satellite cells. However, these findings are controversial, and the issue remains unresolved.

引用

页码：127 / 133

页数：7

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