Factor XIII (FXIII) and angiogenesis

被引：91

作者：

Dardik, R

Loscalzo, J

Inbal, A ^{[1
]}

机构：

[1] Chaim Sheba Med Ctr, Inst Thrombosis & Hemostasis, IL-52621 Tel Hashomer, Israel

[2] Tel Aviv Univ, Sackler Fac Med, Inst Thrombosis & Hemostasis, IL-69978 Tel Aviv, Israel

[3] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Boston, MA 02118 USA

[4] Boston Univ, Sch Med, Evans Dept Med, Boston, MA 02118 USA

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2006年 / 4卷 / 01期

关键词：

D O I：

10.1111/j.1538-7836.2005.01473.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Factor XIII is a plasma transglutaminase that participates in the final stage of the coagulation cascade. Thrombin-activated FXIII (FXIIIa) catalyzes the formation of covalent cross-links between gamma-glutamyl and epsilon-lysyl residues on adjacent fibrin chains in polymerized fibrin to yield the mature clot. In addition to its role in hemostasis, FXIII is known to participate in wound healing and embryo implantation, which are processes involving angiogenesis. In this review, we discuss the role of FXIII in angiogenesis and the molecular mechanisms underlying its proangiogenic effects. The FXIII role in tissue repair and remodeling may at least in part be attributed to its pro-angiogenic activity.

引用

页码：19 / 25

页数：7

共 87 条

[1] Factor XIIIA transglutaminase crosslinks AT1 receptor dimers of monocytes at the onset of atherosclerosis [J].