The possible role of nitric oxide in the physiopathology of pain associated with temporomandibular joint disorders

被引：26

作者：

Anbar, M ^{[1
]}

Gratt, BM

机构：

[1] SUNY Buffalo, Sch Med, Buffalo, NY 14214 USA

[2] Maxillofacial Dent Radiol Consultants, Mercer Isl, WA USA

[3] Univ Calif Los Angeles, Sch Dent, Sect Oral Radiol, Los Angeles, CA 90024 USA

来源：

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 1998年 / 56卷 / 07期

关键词：

D O I：

10.1016/S0278-2391(98)90018-0

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Temporomandibular joint disorders (TMD) pose a significant challenge to the practice of oral and maxillofacial surgery. When painful, TMD are generally associated with hyperthermia of the overlying skin. It is hypothesized that this skin hyperthermia, caused by regional vasodilation, is induced by nitric oxide (NO) produced in the extravascular space of the joint. Extravascular NO can be produced by osteoblasts, chondrocytes and macrophages, or by stimulated neurons. It is suggested that this kind of pain is associated with NO-enhanced sensitivity of the peripheral nociceptors. Verification and clinical implications of the proposed mechanism are discussed.

引用

页码：872 / 882

页数：11

共 183 条

[1] Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent pain [J].