Probiotics and the gut microbiota in intestinal health and disease

被引：628

作者：

Gareau, Melanie G. ^{[1
]}

Sherman, Philip M. ^{[1
]}

Walker, W. Allan ^{[2
]}

机构：

[1] Univ Toronto, Hosp Sick Children, Res Inst, Cell Biol Program, Toronto, ON M5G 1X8, Canada

[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp Children, Mucosal Immunol Lab,Gastroenterol Div, Charlestown, MA 02129 USA

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2010年 / 7卷 / 09期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

IRRITABLE-BOWEL-SYNDROME; ANTIBIOTIC-ASSOCIATED DIARRHEA; ACUTE INFECTIOUS DIARRHEA; TREATING ACUTE DIARRHEA; WEIGHT PRETERM INFANTS; LACTOBACILLUS-CASEI; DOUBLE-BLIND; NECROTIZING ENTEROCOLITIS; SACCHAROMYCES-BOULARDII; EPITHELIAL BARRIER;

D O I：

10.1038/nrgastro.2010.117

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The use of probiotics is increasing in popularity for both the prevention and treatment of a variety of diseases. While a growing number of well-conducted, prospective, randomized, controlled, clinical trials are emerging and investigations of underlying mechanisms of action are being undertaken, questions remain with respect to the specific immune and physiological effects of probiotics in health and disease. This Review considers recent advances in clinical trials of probiotics for intestinal disorders in both adult and pediatric populations. An overview of recent in vitro and in vivo research related to potential mechanisms of action of various probiotic formulations is also considered.

引用

页码：503 / 514

页数：12

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