Synthesis of 3′-, 4′- and 6′-deoxy and other analogues of D-glucosaminylphosphatidylinositol

被引：5

作者：

Borissow, CN

Smith, TK

Ferguson, MAJ

Brimacombe, JS ^{[1
]}

机构：

[1] Univ Dundee, Dept Chem, Dundee DD1 4HN, Scotland

[2] Univ Dundee, Dept Biochem, Dundee DD1 4HN, Scotland

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 01期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

glycosylphosphatidylinositol (GPI) membrane anchors; D-glucosaminylphosphatidylinositol analogues; GPI biosynthesis;

D O I：

10.1016/S0040-4039(00)01901-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Deoxy and other analogues of D-glucosaminylphosphatidylinositol 1 have been synthesised and tested as substrates or inhibitors of a de-N-acetylase and mannosyltransferase (MT-1) involved in the biosynthesis of the glycosylphosphatidylinositol (GPI) membrane anchor of the parasite Trypanosoma brucei. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：121 / 123

页数：3

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