Role of the rep helicase gene in homologous recombination in Neisseria gonorrhoeae

被引:31
作者
Kline, KA [1 ]
Seifert, HS [1 ]
机构
[1] Northwestern Univ, Feinberg Univ, Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA
关键词
D O I
10.1128/JB.187.8.2903-2907.2005
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
In Escherichia coli, the Rep helicase has been implicated in replication fork progression, replication restart, homologous recombination, and DNA repair. We show that a Neisseria gonorrhoeae rep mutant is deficient in the homologous-recombination-mediated processes of DNA transformation and pilus-based colony variation but not in DNA repair.
引用
收藏
页码:2903 / 2907
页数:5
相关论文
共 47 条
[1]   FACTORS AFFECTING GENETIC TRANSFORMATION OF NEISSERIA-GONORRHOEAE [J].
BISWAS, GD ;
SOX, T ;
BLACKMAN, E ;
SPARLING, PF .
JOURNAL OF BACTERIOLOGY, 1977, 129 (02) :983-992
[2]   Absence of an SOS-like system in Neisseria gonorrhoeae [J].
Black, CG ;
Fyfe, JAM ;
Davies, JK .
GENE, 1998, 208 (01) :61-66
[3]   Viability of rep recA mutants depends on their capacity to cope with spontaneous oxidative damage and on the DnaK chaperone protein [J].
Bredèche, MF ;
Ehrlich, SD ;
Michel, B .
JOURNAL OF BACTERIOLOGY, 2001, 183 (07) :2165-2171
[4]   CHARACTERIZATION OF REP- MUTANTS AND THEIR INTERACTION WITH P2-PHAGE [J].
CALENDAR, R ;
LINDQVIST, B ;
SIRONI, G ;
CLARK, AJ .
VIROLOGY, 1970, 40 (01) :72-+
[5]   A mutant form of the Neisseria gonorrhoeae pilus secretin protein PilQ allows increased entry of heme and antimicrobial compounds [J].
Chen, CJ ;
Tobiason, DM ;
Thomas, CE ;
Shafer, WM ;
Seifert, HS ;
Sparling, PF .
JOURNAL OF BACTERIOLOGY, 2004, 186 (03) :730-739
[6]   THE ESCHERICHIA-COLI REP MUTATION .10. CONSEQUENCES OF INCREASED AND DECREASED REP PROTEIN-LEVELS [J].
COLASANTI, J ;
DENHARDT, DT .
MOLECULAR & GENERAL GENETICS, 1987, 209 (02) :382-390
[7]   ABORTIVE REPLICATION OF PHIX174 DNA IN A RECOMBINATION-DEFICIENT MUTANT OF ESCHERICHIA COLI [J].
DENHARDT, DT ;
DRESSLER, DH ;
HATHAWAY, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1967, 57 (03) :813-&
[8]   REP MUTATION .2. ITS EFFECT ON ESCHERICHIA-COLI AND ON REPLICATION OF BACTERIOPHAGE-PHIX174 [J].
DENHARDT, DT ;
IWAYA, M ;
LARISON, LL .
VIROLOGY, 1972, 49 (02) :486-+
[9]   DNA gyrase, topoisomerase IV, and the 4-quinolones [J].
Drlica, K ;
Zhao, XL .
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 1997, 61 (03) :377-+
[10]   THE OVEREXPRESSION AND COMPLETE AMINO-ACID-SEQUENCE OF ESCHERICHIA-COLI 3-DEHYDROQUINASE [J].
DUNCAN, K ;
CHAUDHURI, S ;
CAMPBELL, MS ;
COGGINS, JR .
BIOCHEMICAL JOURNAL, 1986, 238 (02) :475-483