Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation

被引：123

作者：

Aldieri, E ^{[1
]}

Atragene, D ^{[1
]}

Bergandi, L ^{[1
]}

Riganti, C ^{[1
]}

Costamagna, C ^{[1
]}

Bosia, A ^{[1
]}

Ghigo, D ^{[1
]}

机构：

[1] Univ Turin, Dept Genet Biol & Biochem, Sez Biochim, I-10126 Turin, Italy

来源：

FEBS LETTERS | 2003年 / 552卷 / 2-3期

关键词：

nitric oxide; nitric oxide synthase; artemisinin; parthenolide; malaria; NF-kB; IkB-alpha;

D O I：

10.1016/S0014-5793(03)00905-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Artemisinin is a natural product used as an alternative drug in the treatment of severe and multidrug-resistant malaria. In the present work we show that artemisinin shares with other sesquiterpene lactones the ability to inhibit the activation of the nuclear factor NF-kB: by this mechanism, artemisinin, as well as parthenolide, inhibits nitric oxide synthesis in cytokine-stimulated human astrocytoma T67 cells. These results suggest that artemisinin, in addition to its antiparasitic properties, could also exert a therapeutic effect on neurological complications of malaria. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：141 / 144

页数：4

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