A DNA array sensor utilizing magnetic microbeads and magnetoelectronic detection

被引：211

作者：

Miller, MM ^{[1
]}

Sheehan, PE ^{[1
]}

Edelstein, RL ^{[1
]}

Tamanaha, CR ^{[1
]}

Zhong, L ^{[1
]}

Bounnak, S ^{[1
]}

Whitman, LJ ^{[1
]}

Colton, RJ ^{[1
]}

机构：

[1] USN, Res Lab, Washington, DC 20375 USA

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2001年 / 225卷 / 1-2期

关键词：

biosensor; GMR; magnetoelectronics; DNA array; DNA hybridization; magnetic beads;

D O I：

10.1016/S0304-8853(00)01242-7

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

We describe a multi-analyte biosensor that uses magnetic microbeads as labels to detect DNA hybridization on a micro-fabricated chip. The beads are detected by giant magnetoresistance (GMR) magnetoelcctronic sensors embedded in the chip. The prototype device is a tabletop unit containing electronics, a chip carrier with a microfluidic flow cell, and a compact electromagnet and is capable of simultaneous detection of eight different analytes. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：138 / 144

页数：7

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