The molecular puzzle of two-component signaling cascades

被引：35

作者：

Foussard, M ^{[1
]}

Cabantous, S ^{[1
]}

Pédelacq, JD ^{[1
]}

Guillet, V ^{[1
]}

Tranier, S ^{[1
]}

Mourey, L ^{[1
]}

Birck, C ^{[1
]}

Samama, JP ^{[1
]}

机构：

[1] CNRS, IPBS, Grp Cristallog Biol, F-31077 Toulouse, France

来源：

MICROBES AND INFECTION | 2001年 / 3卷 / 05期

关键词：

two-component systems; signal transduction; functional domains;

D O I：

10.1016/S1286-4579(01)01390-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Two-component systems constitute prevalent signaling pathways in bacteria and mediate a large variety of adaptative cellular responses. Signaling proceeds through His-Asp phosphorelay cascades that involve two central partners, the histidine protein kinase and the response regulator protein. Structural studies have provided insights into some design principles and activation mechanisms of these multi-domain proteins implicated in the control of virulence gene expression in several pathogens. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

页码：417 / 424

页数：8

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