Polyamines: New cues in cellular signal transduction

被引：114

作者：

Bachrach, U ^{[1
]}

Wang, YC ^{[1
]}

Tabib, A ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Mol Biol, IL-91120 Jerusalem, Israel

来源：

NEWS IN PHYSIOLOGICAL SCIENCES | 2001年 / 16卷

关键词：

D O I：

10.1152/physiologyonline.2001.16.3.106

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

The naturally occurring polyamines putrescine, spermidine, and spermine are involved in signal transduction. This has been demonstrated by using inhibitors for polyamine biosynthesis (such as alpha -difluoromethylornithine)or adding polyamines to cultured cells. Different polyamines, preferentially activated protein kinases (tyrosine kinases and MAP kinases), stimulated the expression of nuclear protooncogenes (myc, jun, and fos).

引用

页码：106 / 109

页数：4

共 13 条

[1]

ORNITHINE DECARBOXYLASE ACTIVITY IS CRITICAL FOR CELL-TRANSFORMATION [J].

AUVINEN, M ;

PAASINEN, A ;

ANDERSSON, LC ;

HOLTTA, E .

NATURE, 1992, 360 (6402) :355-358

[2]

AUVINEN M, 1995, MOL CELL BIOL, V15, P6513

[3]

CYCLIC AMP-MEDIATED INDUCTION OF ORNITHINE DECARBOXYLASE OF GLIOMA AND NEUROBLASTOMA-CELLS [J].

BACHRACH, U .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (08) :3087-3091

[4]

BACHRACH U, 1998, COST 917 4 WORKSH BI, P57

[5]

THE ORNITHINE DECARBOXYLASE GENE IS A TRANSCRIPTIONAL TARGET OF C-MYC [J].

BELLOFERNANDEZ, C ;

PACKHAM, G ;

CLEVELAND, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (16) :7804-7808

[6]

Cohen S.S., 1998, GUIDE POLYAMINES

[7]

p44/42 mitogen-activated protein kinase is involved in the expression of ornithine decarboxylase in leukaemia L1210 cells [J].

Flamigni, F ;

Facchini, A ;

Capanni, C ;

Stefanelli, C ;

Tantini, B ;

Caldarera, M .

BIOCHEMICAL JOURNAL, 1999, 341 :363-369

[8]

POLYAMINES AND PROTEIN-KINASE .2. EFFECT OF POLYAMINES ON CYCLIC-AMP - DEPENDENT PROTEIN-KINASE FROM RAT-LIVER [J].

HOCHMAN, J ;

KATZ, A ;

BACHRACH, U .

LIFE SCIENCES, 1978, 22 (17) :1481-1484

[9]

THE RAS SIGNAL-TRANSDUCTION PATHWAY [J].

KHOSRAVIFAR, R ;

DER, CJ .

CANCER AND METASTASIS REVIEWS, 1994, 13 (01) :67-89

[10]

ORNITHINE DECARBOXYLASE - A KEY REGULATORY ENZYME IN NORMAL AND NEOPLASTIC GROWTH [J].

RUSSELL, DH .

DRUG METABOLISM REVIEWS, 1985, 16 (1-2) :1-88

← 1 2 →